Bound For Destruction: Ubiquitination Protects Against Improper Notch Signaling

The Notch pathway is an important molecular signaling mechanism whose existence has been known, or at least hinted at, for nearly a century since the identification of a mutant strain of Drosophila fruit flies with "notched" wings in Thomas Hunt Morgan's lab in 1910.Notch is activated by a protease that is present ubiquitously in the cell ...

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